meropenem coverage pneumonia

Reappraisal of clindamycin IV monotherapy for treatment of mild-to-moderate aspiration pneumonia in elderly patients. Streptococcus pneumoniae is a common pathogen that causes various types of bacterial infections, such as pneumonia, otitis media, occult bacteremia, and meningitis (). Of 255 patients enrolled, 111 were eva … They exhibit low minimum inhibitory concentrations on organisms like methicillin-susceptible S. aureus, S. pyogenes, and S. pneumoniae. USA.gov. In Japan, an increase in the elderly population is associated with an increased incidence of aspiration pneumonia. Meropenem Fresenius Kabi 500 mg poeder voor oplossing voor injectie of infusie Meropenem Fresenius Kabi 1 g poeder voor oplossing voor injectie of infusie Meropenem Lees goed de hele bijsluiter voordat u dit geneesmiddel gaat gebruiken want er staat belangrijke informatie in voor u. The role of gram-negative bacteria in healthcare-associated pneumonia. NIH pneumonia, intra-abdominal infection, gynecologic infection, ... clindamycin, or moxifloxacin provide excellent anaerobic coverage for aspiration pneumonia. This site needs JavaScript to work properly. 1999 Jan;115(1):178-83. doi: 10.1378/chest.115.1.178. S. pneumoniae is enclosed in a complex polysaccharide capsule that can be used to classify strains into serotypes. Coverage for atypical organisms in patients with pneumonia, especially in the following situations: 1) Patients who are at some risk for community-acquired MRSA pneumonia, but not enough risk to justify addition of linezolid or vancomycin (doxycycline has fair activity against community-acquired MRSA, but lacks evidence for efficacy in MRSA pneumonia). - Bewaar deze bijsluiter. doi: 10.1371/journal.pone.0073396. Of the 111 pathogens detected (14 anaerobic pathogens remained unidentified), anaerobic bacteria accounted for 19.8% and gram-negative enteric bacilli made up 19.8%. Background: Treatment of aspiration pneumonia is an important problem due to aging of populations worldwide. 2013 Apr;19(2):291-8. doi: 10.1007/s10156-013-0552-6. 2009;48(3):129-35. doi: 10.2169/internalmedicine.48.1308. The overall satisfactory response rate for individual pretreatment pathogens ranged from 65% to 100%. 1000 mg, poeder voor oplossing voor injectie of infusie 1000 mg meropenem Lees goed de hele bijsluiter voordat u dit geneesmiddel gaat gebruiken want er staat belangrijke informatie in voor u. Yamamoto Y, Izumikawa K, Morinaga Y, Nakamura S, Kurihara S, Imamura Y, Miyazaki T, Tsukamoto M, Kakeya H, Yanagihara K, Yasuoka A, Kohno S. J Infect Chemother. Postgrad Med. Treatment guidelines for aspiration pneumonia recommend the use of antibiotics effective against anaerobic bacteria, such as carbapenems. This study demonstrates that meropenem monotherapy is effective and well tolerated for patients with hospital-acquired pneumonia, including a subgroup of patients with ventilator-associated pneumonia. Methods: 2009 Feb;30(1):61-6. doi: 10.1055/s-0028-1119810. Please enable it to take advantage of the complete set of features! Objective and background: Comparison of the Effects of Sugammadex, Neostigmine, and Pyridostigmine on Postoperative Nausea and Vomiting: A Propensity Matched Study of Five Hospitals. NLM Meropenem therapy for aspiration pneumonia is clinically effective and tolerable in elderly patients. The anti-Pseudomonas aeruginosa antibody Panobacumab is efficacious on acute pneumonia in neutropenic mice and has additive effects with meropenem. APEKS-NP was a multicenter, double-blind, parallel-group trial that compared the all-cause mortality of cefiderocol at Day 14 to high-dose meropenem in 300 adults with nosocomial pneumonia. 2003 Mar;113(3):99-102, 105-6, 111-2. doi: 10.3810/pgm.2003.03.1390. Rifampicin susc … Patients from 28 centers in the USA received meropenem 1 g every 8 h intravenously. Background Current guidelines of empirical antibiotic treatment for inpatients with community-acquired pneumonia recommend antibiotics whose spectrum covers intracellular (atypical) pathogens. NLM A prospective study of 62 elderly hospitalized patients with aspiration pneumonia (34 males, 28 females; mean age 86.6 years) was conducted. By continuing to browse this site you are agreeing to our use of cookies. 2019 Dec;4(4):318-328. doi: 10.1177/2396987319851335. The causative organisms of aspiration pneumonia, including anaerobic bacteria, were investigated using fiberoptic bronchoscopy.  |  They have poor coverage of MRSA and enterococcal infections because of their aforementioned intrinsic resistance. The efficacy and tolerability of meropenem as empirical treatment in patients with hospital-acquired pneumonia was determined in a prospective, open-label, non-randomized trial. 2020 Jun 5;20(1):160. doi: 10.1186/s12890-020-01198-4. - Bewaar deze bijsluiter. Detailed Meropenem dosage information for adults and children.  |  Ventilator-associated pneumonia: monotherapy is optimal if chosen wisely. excellent anaerobic coverage for aspiration pneumonia. Combination and meropenem treatments also showed comparable numbers of reported adverse events, 85.9% and 83.3%, respectively.  |  Methods. Secher T, Fas S, Fauconnier L, Mathieu M, Rutschi O, Ryffel B, Rudolf M. PLoS One. J Clin Med. Get the latest public health information from CDC: https://www.coronavirus.gov. In addition, the efficacy and safety of intravenous meropenem for this treatment of this condition were evaluated. The secondary aim of the study was to compare the results of routinely testings and those obtained by a referent laboratory. Meropenem is indicated for the treatment of complicated intra-abdominal infections caused by E. coli, Klebsiella pneumoniae, P. aeruginosa, B. fragilis, Bacteroides thetaiotaomicron, and Peptostreptococcus species , at a dosage of 1 g every 8 h for adults and 20 mg/kg every 8 h (to a maximum of 1 g) for children, infused over 15–30 min (or administered by bolus injection over 3–5 … Get the latest research from NIH: https://www.nih.gov/coronavirus. Efficacy of meropenem as monotherapy in the treatment of ventilator-associated pneumonia. In this open-label, randomized study, either cefepime 1 g or meropenem 0.5 g was administered intravenously every 8 h to patients with moderate-to-severe community-acquired or nursing-home acquired pneumonia at risk for aspiration for an average of 10.5 days. Alvarez-Lerma F, Grau S, Alvarez-Beltrán M. Clin Microbiol Infect. 2020 Oct 28;9(11):3477. doi: 10.3390/jcm9113477. eCollection 2013. Antibiotics for Aspiration Pneumonia in Neurologically Impaired Children. Hamao N, Ito I, Konishi S, Tanabe N, Shirata M, Oi I, Tsukino M, Matsumoto H, Yasutomo Y, Kadowaki S, Hirai T. BMC Pulm Med. Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Meropenem therapy for aspiration pneumonia is clinically effective and tolerable in elderly patients. Some of these include meningitis, intra-abdominal infection, pneumonia, sepsis, and anthrax. In this randomized, phase 3, non-inferiority trial, adults aged 18 years or older with hospital-acquired, ventilator- or, healthcare-associated Gram-negative pneumonia were enrolled. HHS Kadowaki M, Demura Y, Mizuno S, Uesaka D, Ameshima S, Miyamori I, Ishizaki T. Chest. No sufficient evidence exists to support the necessity of such coverage, whereas limiting it may reduce toxic effects, resistance, and expense. 2006;10(2):141. doi: 10.1186/cc4908. Epub 2006 Jan 31. Epub 2019 Nov 20. Aspiration ... meropenem (88%) vs. clindamycin plus gentamicin (90%). COVID-19 is an emerging, rapidly evolving situation. It is given by injection into a vein. At end of treatment 74% of patients had a satisfactory clinical response and 64% had this response at follow-up, which could last up to 28 days after treatment. Meropenem Antibiotic Class: Carbapenem Antimicrobial Spectrum: Aerobic gram-positive microorganisms: S. aureus including penicillinase-producing strains, Group D streptococcus including Enterococcus spp., Streptococcus pneumoniae, S. pyogenes, S. viridans group The results suggest that cefiderocol is a potential option for the treatment of patients with nosocomial pneumonia, including those caused by multidrug-resistant Gram-negative bacteria. Most of the adverse event drug discontinuations were a result of fatal adverse events and not because of decisions made by researchers, which occurred in 24 of 37 cases in the combination group and 28 of 31 cases in the meropenem group where patients … Gram-Positive Coverage 1,2 Generally, carbapenems work against various Gram-positive bacteria. Clipboard, Search History, and several other advanced features are temporarily unavailable. This site needs JavaScript to work properly. Get the latest research from NIH: https://www.nih.gov/coronavirus. Otsuji K, Fukuda K, Ogawa M, Fujino Y, Kamochi M, Saito M. BMC Pulm Med. However, the role of anaerobic bacteria in aspiration pneumonia and the clinical efficacy of meropenem in elderly aspiration pneumonia patients have only begun to be investigated. Cefiderocol was non-inferior to high-dose, extended-infusion meropenem in terms of all-cause mortality on day 14 in patients with Gram-negative nosocomial pneumonia, with similar tolerability. Aim: To compare the clinical efficacy and safety of cefepime and meropenem in patients with moderate-to-severe aspiration pneumonia. Meropenem by continuous versus intermittent infusion in ventilator-associated pneumonia due to gram-negative bacilli.  |  • Broncho-pulmonary infections in cystic fibrosis • … Of 255 patients enrolled, 111 were evaluable for efficacy, including 60 patients with ventilator-associated pneumonia. In-vitro susceptibility of 299 Neisseria meningitidis and 157 Streptococcus pneumoniae strains from meningitis patients in The Netherlands in 1993 and 1994 to meropenem was determined using the Etest. 2001 Feb;13(1):70-81. doi: 10.1179/joc.2001.13.1.70.  |  Dtsch Med Wochenschr. 2019 Dec 23;19(1):260. doi: 10.1186/s12890-019-1021-5. Thomson J, Hall M, Ambroggio L, Berry JG, Stone B, Srivastava R, Shah SS. Aspiration pneumonia. Conclusion: Antibiotic treatment for pneumonia complicating stroke: Recommendations from the pneumonia in stroke consensus (PISCES) group. 2020 Jul 1;15(7):395-402. doi: 10.12788/jhm.3338. Meropenem is a carbapenem that has an excellent activity against many gram-positive and gram-negative aerobic, ... pneumonia (29%), peritonitis (12%) and wound infections (3%), in 15 French hospitals in 2006. •Conclusion: A regimen of 500mg IV q6h is able to achieve a similar probability of target attainment with However, the utility of “continued double-coverage” (after susceptibilities identified) is a long-standing point of controversy – some experts recommend this for serious infections including bacteremia in neutropenic patients, endocarditis, meningitis, and possibly pneumonia. Effectiveness of meropenem for the treatment of aspiration pneumonia in elderly patients Intern Med. J Hosp Med. Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. KEY POINTS Meropenem (Merrem) is an injectable carbapenem and beta-lactam antibiotic that interferes with bacterial cell wall synthesis in sensitive organisms Has activity versus a wide array of organisms, including multi-drug resistant Acinetobacter baumannii, Pseudomonas aeruginosa and Klebsiella pneumoniae DOES NOT cover MRSA or VRE Carbapenems like meropenem are generally considered … The abstract, “Efficacy and Safety of Cefiderocol versus High-Dose Meropenem in Patients with Nosocomial Pneumonia — Results of a Phase 3 Randomized, Multicenter, Double-Blind, Non-Inferiority Study,” was presented in a late breaking oral abstract session … So far, at least 92 structurally and serologically distinct serotypes have been recognized ().  |  2006 May;12 Suppl 3:81-92. doi: 10.1111/j.1469-0691.2006.01399.x. The microbiologic eradication rate was also high, with a median of over 90% (range 88-100%). Prospective randomized comparison study of piperacillin/tazobactam and meropenem for healthcare-associated pneumonia in Japan. USA.gov. Adults with nosocomial pneumonia (including ventilator-associated pneumonia), enrolled at 136 centres in 23 countries, were randomly assigned (1:1) to 2000 mg ceftazidime and 500 mg avibactam (by 2 h intravenous infusion every 8 h) or 1000 mg meropenem (by 30-min intravenous infusion every 8 h) for 7–14 days; regimens were adjusted for renal function. Dynamics of microbiota during mechanical ventilation in aspiration pneumonia. Includes dosages for Skin and Structure Infection, Intraabdominal Infection, Nosocomial Pneumonia and more; plus renal, liver and dialysis adjustments. Epub 2013 Jan 24. Kishore AK, Jeans AR, Garau J, Bustamante A, Kalra L, Langhorne P, Chamorro A, Urra X, Katan M, Napoli MD, Westendorp W, Nederkoorn PJ, van de Beek D, Roffe C, Woodhead M, Montaner J, Meisel A, Smith CJ. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error, J-STAGE, Japan Science and Technology Information Aggregator, Electronic. Epub 2019 May 27. Crit Care. Recognizing and managing a potentially growing disorder. Meropenem is indicated for the treatment of the following infections in adults and children aged 3 months and older (see sections 4.4 and 5.1): • Severe pneumonia, including hospital and ventilator-associated pneumonia. Eur Stroke J. No fetal toxicity or malformations were observed in pregnant rats and Cynomolgus monkeys administered intravenous meropenem during organogenesis at doses up to 2.4 and 2.3 times the maximum recommended human dose (MRHD) based on body surface area comparison, respectively; in rats administered intravenous meropenem in late pregnancy and during lactation period, there were no … Alvarez Lerma F; Serious Infection Study Group. Toepassing komt met name in aanmerking bij ernstige abdominale infecties en bij neutropene patiënten. Susceptibility to penicillin, ceftriaxone, and chloramphenicol was also determined. In het algemeen: Toepassing van meropenem dient te worden gereserveerd voor ernstige infecties waarbij penicillinen of cefalosporinen onvoldoende effectief zijn. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. NIH HHS The efficacy and tolerability of meropenem as empirical treatment in patients with hospital-acquired pneumonia was determined in a prospective, open-label, non-randomized trial. Ann Pharmacother. Meronem i.v. The antibacterial activities of imipenem-cilastatin, meropenem-cilastatin, cefepime and ceftazidime against Enterobacter cloacae NOR-1, which produces the carbapenem-hydrolyzing beta-lactamase NmcA and a cephalosporinase, and against one of its in vitro-obtained ceftazidime-resistant mutant were compared by using an experimental model of pneumonia with immunocompetent rats. Merrem Hospital-Acquired Pneumonia Study Group. The overall clinical efficacy rate of meropenem therapy (1.0 g/day) was 61.3%. The overall detection rate of bacteria was 87.1% (monomicrobial, 32.3%; polymicrobial, 54.8%). Chest. Meropenem, sold under the brandname Merrem among others, is a broad-spectrum antibiotic used to treat a variety of bacterial infections. Bartoloni A, Strohmeyer M, Corti G, Buonomini MI, Franchino L, Romanelli G, Moretti AM, De Vizzi GB, Petraglia A, Mancini P, Atzeni R, Fogliani V, Giura R, Paradisi F. Semin Respir Crit Care Med. Epub 2009 Feb 6. Kim JH, Lim MS, Choi JW, Kim H, Kwon YS, Lee JJ. Results: {{configCtrl2.info.metaDescription}} This site uses cookies. Lorente L, Lorenzo L, Martín MM, Jiménez A, Mora ML. INTRODUCTION  Community-acquired pneumonia (CAP) is defined as an acute infection of the pulmonary parenchyma in a patient who has acquired the infection in the community, as distinguished from hospital-acquired (nosocomial) pneumonia (HAP). Misschien heeft u hem later weer nodig. However, the effectiveness of cefepime in aspiration pneumonia has not yet been evaluated. Multicenter randomized trial comparing meropenem (1.5 g daily) and imipenem/cilastatin (2 g daily) in the hospital treatment of community-acquired pneumonia. When disease severity was classified according to the Japanese Respiratory Society (JRS) guidelines, 80.7% of the cases in this study were graded as "most severe". Clinical Need and Target Population Community-acquired pneumonia (CAP) is a common condition worldwide that can sometimes lead to hospitalization. The mortality rate was 9.7%, and anaerobic bacteria coexisted with aerobic bacteria in 66.7% of the patients who died. 500 mg, poeder voor oplossing voor injectie of infusie 500 mg Meronem i.v. J Chemother. Culture, gram strain of tracheal aspirate or lavage fluid should be performed in all cases of suspected VAP. In patients with ventilator-associated pneumonia, a satisfactory clinical response was observed in 68% at the end of treatment and 63% at follow-up. Comparison of ceftriaxone plus macrolide and ampicillin/sulbactam plus macrolide in treatment for patients with community-acquired pneumonia without risk factors for aspiration: an open-label, quasi-randomized, controlled trial. The intent-to-treat population consisted of 726 patients who were randomly assigned to receive either a 3-g combination of 2 g ceftolozane and 1 g tazobactam (n=362) or 1 g meropenem (n=364); both groups were administered their respective treatments as 1-hour infusions every 8 hours for 8 to 14 days. meropenem vergelijken met een ander geneesmiddel.. Advies. The microbiologic eradication rate was also Patients from 28 centers in the USA received meropenem 1 g every 8 h intravenously. Misschien heeft u hem later weer nodig. 2006 Feb;40(2):219-23. doi: 10.1345/aph.1G467. 2013 Sep 2;8(9):e73396. [Diagnosis and therapy of aspiration pneumonia]. 2006 Mar 24;131(12):624-8. doi: 10.1055/s-2006-933707. The use of antibiotics effective against anaerobic bacteria may be necessary for patients with potentially fatal aspiration pneumonia. Aspiration pneumonitis follows the aspiration of gastric contents, ... meropenem (88%) vs. clindamycin plus gentamicin (90%). Please enable it to take advantage of the complete set of features! COVID-19 is an emerging, rapidly evolving situation. The role of anaerobes in patients with ventilator-associated pneumonia and aspiration pneumonia: a prospective study. Get the latest public health information from CDC: https://www.coronavirus.gov. Cefiderocol was non-inferior to high-dose, extended infusion meropenem in patients with Gram-negative nosocomial pneumonia, according to a study published in The Lancet Infectious Diseases.. Meropenem Target Attainment vs. P. aeruginosa •Probability of target attainment is similar for doses of 1g IV q8h and 500mg IV q6h (both at the desired probability of ≥90%), up to an MIC of 2 mg/L. This rapid review aims to assess the effectiveness of regimens containing antibiotic coverage for atypical pathogens compared with regimens containing antibiotic coverage for typical pathogens. 2005 Apr;127(4):1276-82. doi: 10.1378/chest.127.4.1276. Levofloxacin in the treatment of ventilator-associated pneumonia. Clipboard, Search History, and several other advanced features are temporarily unavailable.

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